RISC assembly and post-transcriptional gene regulation in Hepatocellular Carcinoma

Post-transcriptional gene regulation in chondrocytes.

The control of gene expression in articular chondrocytes is an essential factor in maintaining the homoeostasis of extracellular matrix synthesis and turnover necessary in healthy articular cartilage. Although much is known of how steady-state levels of gene expression and rates of transcription are altered, there has been a poorer understanding of gene control at the post-transcriptional level...

Post-transcriptional gene regulation in mature neurons

OF THE DISSERTATION ........................................................................... ii DEDICATION .................................................................................................................... v LIST OF FIGURES AND TABLES.................................................................................. ix ACKNOWLEDGMENTS ...........................................

The Role of the 3' Untranslated Region in the Post-Transcriptional Regulation of KLF6 Gene Expression in Hepatocellular Carcinoma

KLF6 is ubiquitously expressed in human tissues and regulates many pathways such as differentiation, development, cellular proliferation, growth-related signal transduction, and apoptosis. We previously demonstrated that KLF6 expression is altered during liver carcinogenesis. More importantly, KLF6 invalidation results in cell cycle progression inhibition and apoptosis of liver cancer cells. On...

Post-Transcriptional Regulation of Papillomavirus Gene Expression

Papillomavirus genomes are transcribed as one large complex transcription unit with multiple promoters, two poly(A) sites (early and late), and considerable alternative splicing. As a result, there are multiple opportunities for post-transcriptional regulation of papillomavirus gene expression. Although this area has not been as extensively studied as transcriptional regulation, there are a few...

Hepatocellular Carcinoma in Sheep